| Jornada 1 | 28-08-2005 | VALENCIA | 1 | BETIS | 0 |
| Jornada 2 | 11-09-2005 | BETIS | 1 | OSASUNA | 0 |
| Jornada 3 | 18-09-2005 | BETIS | 0 | ZARAGOZA | 0 |
| Jornada 4 | 21-09-2005 | DEPORTIVO | 1 | BETIS | 1 |
| Jornada 5 | 25-09-2005 | BETIS | 1 | FC BARCELONA | 4 |
| Jornada 6 | 02-10-2005 | REAL SOCIEDAD | 1 | BETIS | 1 |
| Jornada 7 | 16-10-2005 | BETIS | 1 | GETAFE | 0 |
| Jornada 8 | 23-10-2005 | MALAGA | 5 | BETIS | 0 |
| Jornada 9 | 30-10-2005 | BETIS | 0 | REAL MADRID | 2 |
| Jornada 10 | 06-11-2005 | RAC.SANTANDER | 1 | BETIS | 1 |
| Jornada 11 | 09-11-2005 | BETIS | 2 | VILLARREAL | 3 |
| Jornada 12 | 20-11-2005 | SEVILLA | 1 | BETIS | 0 |
| Jornada 13 | 27-11-2005 | BETIS | 1 | CADIZ | 1 |
| Jornada 14 | 04-12-2005 | CELTA | 2 | BETIS | 1 |
| Jornada 15 | 11-12-2005 | BETIS | 0 | ESPANYOL | 0 |
| Jornada 16 | 18-12-2005 | ATHLETIC BILBAO | 2 | BETIS | 0 |
| Jornada 17 | 21-12-2005 | BETIS | 3 | ALAVES | 0 |
| Jornada 18 | 08-01-2006 | MALLORCA | 1 | BETIS | 1 |
| Jornada 19 | 15-01-2006 | BETIS | 1 | ATLETICO MADRID | 0 |
| Jornada 20 | 22-01-2006 | BETIS | 0 | VALENCIA | 2 |
| Jornada 21 | 29-01-2006 | OSASUNA | 0 | BETIS | 2 |
| Jornada 22 | 05-02-2006 | ZARAGOZA | 4 | BETIS | 3 |
| Jornada 23 | 12-02-2006 | BETIS | 0 | DEPORTIVO | 1 |
| Jornada 24 | 19-02-2006 | FC BARCELONA | 5 | BETIS | 1 |
| Jornada 25 | 26-02-2006 | BETIS | 2 | REAL SOCIEDAD | 0 |
| Jornada 26 | 05-03-2006 | GETAFE | 1 | BETIS | 0 |
| Jornada 27 | 12-03-2006 | BETIS | 1 | MALAGA | 1 |
| Jornada 28 | 19-03-2006 | REAL MADRID | 0 | BETIS | 0 |
| Jornada 29 | 22-03-2006 | BETIS | 1 | RAC.SANTANDER | 0 |
| Jornada 30 | 26-03-2006 | VILLARREAL | 1 | BETIS | 2 |
| Jornada 31 | 02-04-2006 | BETIS | 2 | SEVILLA | 1 |
| Jornada 32 | 09-04-2006 | CADIZ | 1 | BETIS | 1 |
| Jornada 33 | 16-04-2006 | BETIS | 0 | CELTA | 2 |
| Jornada 34 | 23-04-2006 | ESPANYOL | 2 | BETIS | 0 |
| Jornada 35 | 30-04-2006 | BETIS | 1 | ATHLETIC BILBAO | 1 |
| Jornada 36 | 03-05-2006 | ALAVES | 2 | BETIS | 0 |
| Jornada 37 | 07-05-2006 | BETIS | 2 | MALLORCA | 1 |
| Jornada 38 | 14-05-2006 | ATLETICO MADRID | 1 | BETIS | 1 |